WOUNDCHEK™ Protease Status
Why test for EPA?
Chronic wounds with elevated protease activity (EPA)
have a 90% probability they won’t heal1 (without appropriate intervention)
only 28% of non-healing wounds have EPA1
there are no visual cues to detect EPA2,3
Non-healing wounds cost billions to the healthcare system4,5
So, how do you know which wounds have EPA?
Developed to aid wound assessment and help clinicians target advanced wound care therapies more effectively, WOUNDCHEK™ Protease Status is able to detect EPA. As there are no clinical signs for EPA, wounds with EPA have so far gone undetected2,3. WOUNDCHEK™ Protease Status will help clinicians establish within minutes which wounds may most benefit from a protease modulating therapy, ensuring appropriate and targeted use of these therapies.
Please refer in full to the Instructions for use leaflet provided in the product packaging, specific to your region.
Systagenix is not responsible for the content of external websites.
- Preliminary results:Testing for elevated protease activity in clinical practice
- Assessing chronic diabetic foot wounds for elevated protease levels
- Using a protease test to inform wound care treatment decisions
The product information on this page is not intended for, or to be used by health care professionals or users in the United States
WOUNDCHEK™ Protease Status references
1. Serena T. et al. Protease activity levels associated with healing status of chronic wounds.Poster, Wounds UK 2011.
2. Snyder RJ, Cullen B, Nisbet LT. An audit to assess the perspectives of US wound care specialists regarding the importance of proteases in wound healing and wound assessment. International Wound Journal 2012; 29 July online publication.
3. International consensus. The role of proteases in wound diagnostics. An expert working group review. London: Wounds International, 2011.
4. Gordois A, Scuffham P, Shearer A, Oglesby A, Tobian JA. The healthcare costs of diabetic peripheral neuropathy in the US. Diabetes Care. 2003;26(6):1790–1795.
5. Shearer A, Scuffham P, Gordois A, Oglesby A. Predicted costs and outcomes from reduced vibration detection in people with diabetes in the U.S. Diabetes Care. 2003;26(8):2305–2310.
6. Instructions for Use 2011.
7. Lazarus GS, Cooper DM, Knighton DR, et al. Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol. 1994;130(4):489-493.
8. Consensus on Use of a Diagnostic Tool in Stalled Wounds to Identify Excess Protease Levels. The Protease Diagnostic Consensus Panel. Ostomy Wound Management. Ostomy Wound Management 2011;57(12): 36-48.